1412 Title: Ocular hypotensive effects of PhCA41 in glaucoma patients and IOP change during day and night in normal volunteers

of Purpose: A comparison of long term effect on IOP and complications trabeculectomies performed with the adjunct of either postoperative 5 fluorouracil(5FU) or peroperative mitomycin C(MMC) in 100 cases of high risk glaucoma. &&&We prospectwly studied 52 eyes of46 patients treated with MMC (Follow up 15i8.7111) and compared it with a retrospective scrie of48 eyes 01 35 patients treated with 5FU (Follow up 14,3li 11,25m). &w&84% of MMC patients but 46% of 5FU group had a normalized 101’ without treatment, and 23% of 5FU vs 5,7 % of MMC patients required systemic glaucoma therapy. Early adverse effects were more’frequently observed with 5FU (cornea 39%, conjonctiva 17% or hypotony 29%) than with MMC (13,46%, 3,85%,13,46% rcspectivly). At last examination, bleb failure requiring additional surgery was more frequent in 5FU group (10%) than MMC (3%), and was mostly associated to anterior chamber factors (i.e. vitreous or lens rclatcd obstruction), rnthcr than cpisclcrnl cclluln~ li~c~owl.o~~g km hypotony was obscrvcd in il l 17.3 % ol the MMC cycs. in this later group 5 of 9 patients had more than 2 lines of best corrected visual acuity reduction. Conclusion: l’hesc results suggest that MMC is ot Icut as cl’licicnt 10 reduce lOP.The use of MMC may be associated with a higher rate of long term hypotony.